ITGAE

Across TCGA pan-cancer cohorts, ITGAE mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ITGAE’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ITGAE mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ITGAE is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

LSCC, PDAC, and HNSC are the cancer types where ITGAE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITGAE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	II,III,IV	−0.369	.007	6	view →
PDAC	Female	All	+0.872	.001	5	view →
HNSC	Male	All	+0.322	.007	5	view →
LUAD	All	II,III,IV	−0.220	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ITGAE–LSCC

Open the LSCC breakdown →