ITGAE

Across TCGA patient cohorts, ITGAE RNA expression is significantly associated with the mutation status of many other genes, with 13,604 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGAE-associated genes across cancer lineages are PIK3CA, EP300, and AKAP9. Each is linked with ITGAE in more than 4 cancer types. Because this analysis shows association rather than direction, both ITGAE-to-partner and partner-to-ITGAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIK3CA grouped by ITGAE-low versus ITGAE-high in STAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAE→partner) and Y-score (partner→ITGAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PIK3CA →	+3.476	+0.649	<.001	<.001	3	5
COAD	EP300 →	+3.827	+0.495	<.001	<.001	3	4
COAD	AKAP9 →	+2.529	+0.499	.001	<.001	3	4
PRAD	TP53 →	-1.813	-0.194	.002	.002	3	4
LUAD	KRAS →	-1.279	-0.232	<.001	<.001	3	4
COAD	LYST →	+3.020	+0.512	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,604 associations by consensus.

PIK3CA by ITGAE expression — STAD

Explore this box plot interactively →