ITGAE

Across TCGA patient cohorts, ITGAE protein abundance is significantly associated with the RNA expression of many other genes, with 7,650 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITGAE-associated genes across cancer lineages are GRAP2, IL2RB, and SLAMF1. Each is linked with ITGAE in more than 5 cancer types. Because this analysis shows association rather than direction, both ITGAE-to-partner and partner-to-ITGAE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITGAE versus GRAP2 in UCEC, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAE→partner) and Y-score (partner→ITGAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GRAP2 →	+1.523	+0.991	<.001	.009	3	6
UCEC	IL2RB →	+1.765	+1.223	<.001	.005	3	6
UCEC	SLAMF1 →	+2.236	+1.275	<.001	.008	3	6
UCEC	CD244 →	+1.744	+1.279	.001	.002	3	6
UCEC	PTPN7 →	+1.997	+1.140	<.001	.001	3	6
UCEC	GPR174 →	+2.318	+1.091	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,650 associations by consensus.

ITGAE vs GRAP2 — UCEC

Explore this scatter interactively →