ITGAE

Across TCGA patient cohorts, ITGAE mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGAE-associated genes across cancer lineages are PRAS40_pT246, c-Met_pY1235, and INPP4B. Each is linked with ITGAE in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGAE-to-partner and partner-to-ITGAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAS40_pT246 grouped by ITGAE-low versus ITGAE-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAE→partner) and Y-score (partner→ITGAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PRAS40_pT246 →	+0.243	+3.179	.003	.010	3	3
LUSC	c-Met_pY1235 →	-0.095	-3.142	.016	.018	3	2
COAD	INPP4B →	-0.388	-3.169	.021	.017	3	2
COAD	PDCD4 →	-0.449	-2.313	.018	.035	3	2
COAD	Smad4 →	+0.142	+3.000	.017	.034	3	2
UCEC	Caspase-8 →	-0.250	-2.000	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PRAS40_pT246 by ITGAE expression — LUSC

Explore this box plot interactively →