ITGAE

Across TCGA cell cohorts, ITGAE RNA expression is significantly associated with the go_rna of many other GO terms, with 3,924 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITGAE-associated GO terms across cancer lineages are Sister chromatid segregation, Mitotic sister chromatid segregation, and Metaphase chromosome alignment. Each is linked with ITGAE in more than 11 cancer types. Because this analysis shows association rather than direction, both ITGAE-to-partner and partner-to-ITGAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid segregation grouped by ITGAE-low versus ITGAE-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAE→partner) and Y-score (partner→ITGAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Sister chromatid segregation →	+0.080	+0.796	.009	.002	3	12
BREAST	Mitotic sister chromatid segregation →	+0.074	+0.640	.003	.004	3	12
BLOOD_Leukemia	Metaphase chromosome alignment →	+0.090	+1.187	<.001	<.001	3	11
BREAST	Regulation of establishment of protein localization to chromosome →	+0.109	+0.929	<.001	<.001	2	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of chromosome condensation →	+0.176	+1.100	.003	.005	3	11
BREAST	Attachment of mitotic spindle microtubules to kinetochore →	+0.138	+0.861	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,924 associations by consensus.

Sister chromatid segregation by ITGAE expression — BREAST

Explore this box plot interactively →