ITGAE

Across TCGA cell cohorts, ITGAE mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITGAE-associated genes across cancer lineages are OR10K2, OR10T2, and CLEC4M. Each is linked with ITGAE in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGAE-to-partner and partner-to-ITGAE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10K2 grouped by ITGAE-low versus ITGAE-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGAE→partner) and Y-score (partner→ITGAE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	2
BLOOD_Leukemia	OR10T2 →	+0.508	+3.106	.001	.005	3	2
LUNG_NSCLC_LUAD	CLEC4M →	+0.032	+3.605	.002	.007	3	2
OVARY	IL1F10 →	+0.128	+2.652	.002	.004	3	1
OVARY	MAGEA8 →	+0.809	+3.206	.009	.008	3	1
OVARY	MS4A14 →	+0.005	+2.754	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OR10K2 by ITGAE expression — BREAST

Explore this box plot interactively →