ITGA5

Across TCGA patient cohorts, ITGA5 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA5-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1_pT37_T46, and Cyclin-B1. Each is linked with ITGA5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ITGA5-to-partner and partner-to-ITGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ITGA5-low versus ITGA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA5→partner) and Y-score (partner→ITGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.388	+2.242	.047	.005	3	3
UCEC	4E-BP1_pT37_T46 →	-0.257	-1.861	.037	.049	3	2
UCEC	Cyclin-B1 →	+0.537	+2.222	.003	.010	3	2
COAD	PDCD4 →	-0.537	-3.450	.004	.005	3	2
COAD	Smad4 →	+0.169	+3.000	.004	.034	3	2
UCEC	14-3-3_beta →	-0.101	-1.973	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Caspase-7-cleavedD198 by ITGA5 expression — UCEC

Explore this box plot interactively →