ITGA5

Across TCGA pan-cancer cohorts, ITGA5 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ITGA5 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ITGA5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ITGA5 expression acts as an unfavorable survival marker, although some lineages such as DLBC and UCS show a favorable association.

UVM, HNSC, and KIRP are the cancer types where ITGA5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.398	0.838	<.001	134	view →
HNSC	OS	Median	All	0.689	0.814	<.001	121	view →
KIRP	DFS	Quartile	All	0.554	0.775	<.001	117	view →
MESO	OS	Median	All	0.240	0.524	<.001	114	view →
CESC	OS	Tertile	All	0.429	0.720	<.001	72	view →
LUSC	DFS	Quartile	All	0.698	0.841	<.001	61	view →
BLCA	OS	Quartile	II,III,IV	0.537	0.748	<.001	60	view →
LGG	DFS	Median	All	0.306	0.519	<.001	54	view →
LIHC	OS	Tertile	All	0.563	0.756	<.001	50	view →
BRCA	DFS	Tertile	II,III,IV	0.860	0.922	.005	43	view →
COAD	DFS	Tertile	All	0.288	0.601	.001	41	view →
STAD	DFS	Median	III,IV	0.369	0.584	.006	40	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ITGA5–UVM (OS)

Open the UVM breakdown →