ITGA5

Across TCGA cell cohorts, ITGA5 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITGA5-associated genes across cancer lineages are KSR2, HPCAL4, and LCN9. Each is linked with ITGA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGA5-to-partner and partner-to-ITGA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by ITGA5-low versus ITGA5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA5→partner) and Y-score (partner→ITGA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KSR2 →	+0.407	+3.798	<.001	.004	3	2
LARGE_INTESTINE	HPCAL4 →	+0.323	+3.302	.001	.008	3	2
BLOOD_Lymphoma	LCN9 →	+0.022	+5.247	<.001	.001	3	1
LUNG_NSCLC_LUAD	OBP2A →	+0.316	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR4L1 →	+0.015	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	GJE1 →	+0.015	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

KSR2 by ITGA5 expression — BLOOD_Leukemia

Explore this box plot interactively →