ITGA4

Across TCGA patient cohorts, ITGA4 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA4-associated genes across cancer lineages are C-Raf, eIF4E, and FASN. Each is linked with ITGA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGA4-to-partner and partner-to-ITGA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ITGA4-low versus ITGA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA4→partner) and Y-score (partner→ITGA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.154	+1.925	<.001	.004	3	4
UCEC	eIF4E →	+0.136	+2.335	.034	.018	3	3
STAD	FASN →	+0.411	+2.823	.035	.034	2	3
LUSC	G6PD →	+0.514	+2.816	.042	.036	3	2
LUSC	Cyclin-B1 →	+0.650	+2.816	.008	.036	3	2
UCEC	14-3-3_beta →	-0.074	-1.651	.015	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

C-Raf by ITGA4 expression — UCEC

Explore this box plot interactively →