ITGA4

Across TCGA pan-cancer cohorts, ITGA4 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ITGA4 data layer compared with 12 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ITGA4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ITGA4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, KIRP, and LUAD are the cancer types where ITGA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.409	0.282	<.001	118	view →
KIRP	DFS	Median	II,III,IV	0.448	1.000	<.001	113	view →
LUAD	DFS	Median	All	0.733	0.603	<.001	108	view →
UVM	DFS	Quartile	II,III,IV	0.335	0.733	.001	97	view →
KIRC	DFS	Tertile	All	0.768	0.510	<.001	68	view →
SKCM	OS	Tertile	II,III,IV	0.508	0.278	<.001	42	view →
LGG	OS	Median	All	0.740	0.879	<.001	38	view →
UCEC	OS	Quartile	II,III,IV	0.745	0.272	.017	24	view →
KICH	DFS	Quartile	II,III,IV	0.571	1.000	.002	20	view →
UCS	DFS	Quartile	III,IV	0.595	0.242	.028	20	view →
CHOL	DFS	Tertile	All	0.686	0.158	.005	18	view →
LIHC	DFS	Quartile	III,IV	0.628	0.150	.003	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ITGA4–HNSC (DFS)

Open the HNSC breakdown →