ITGA4

Across TCGA cell cohorts, ITGA4 mutation is significantly associated with the RNA expression of many other genes, with 161 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ITGA4-associated genes across cancer lineages are C1orf43, CSF2, and OR10A5. Each is linked with ITGA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ITGA4-to-partner and partner-to-ITGA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf43 grouped by ITGA4-low versus ITGA4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA4→partner) and Y-score (partner→ITGA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf43 →	+0.323	+3.212	.008	.006	3	2
LUNG_SCLC	CSF2 →	+0.595	+3.736	<.001	.007	3	1
LUNG_SCLC	OR10A5 →	+0.056	+3.817	<.001	.004	3	1
LUNG_SCLC	OR2D2 →	+0.066	+3.898	<.001	.005	3	1
LUNG_SCLC	BHLHA9 →	+0.046	+3.817	<.001	.004	3	1
LUNG_SCLC	LEUTX →	+0.060	+3.817	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 161 associations by consensus.

C1orf43 by ITGA4 expression — LARGE_INTESTINE

Explore this box plot interactively →