ITGA2

Across TCGA patient cohorts, ITGA2 mutation is significantly associated with the RNA expression of many other genes, with 2,680 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITGA2-associated genes across cancer lineages are KLHL18, BRPF1, and ZNF367. Each is linked with ITGA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ITGA2-to-partner and partner-to-ITGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL18 grouped by ITGA2-low versus ITGA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITGA2→partner) and Y-score (partner→ITGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLHL18 →	+0.447	+2.779	<.001	<.001	3	4
UCEC	BRPF1 →	+0.321	+2.711	.001	.003	3	3
SKCM	ZNF367 →	+0.645	+3.384	.005	.004	3	3
UCEC	GNB1 →	+0.351	+2.671	<.001	<.001	3	3
UCEC	TOX4 →	+0.317	+2.917	.002	<.001	3	3
SKCM	C1orf174 →	+0.424	+2.228	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,680 associations by consensus.

KLHL18 by ITGA2 expression — UCEC

Explore this box plot interactively →