ITCH

Across TCGA pan-cancer cohorts, ITCH mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ITCH data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ITCH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ITCH expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

PDAC, LUAD, and UCEC are the cancer types where ITCH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.314	0.582	.003	24	view →
LUAD	OS	Median	All	0.999	0.921	.012	14	view →
UCEC	OS	Quartile	All	1.000	0.851	.025	14	view →
HNSC	DFS	Tertile	All	0.861	0.654	.012	13	view →
GBM	OS	Quartile	All	1.000	0.753	<.001	11	view →
LSCC	DFS	Tertile	II,III,IV	0.203	0.919	.010	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ITCH–PDAC (DFS)

Open the PDAC breakdown →