ITCH

Across TCGA pan-cancer cohorts, ITCH RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ITCH’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ITCH RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ITCH is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, LUAD, and THCA are the cancer types where ITCH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ITCH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+0.714	.003	8	view →
LUAD	Male	All	+0.567	<.001	8	view →
THCA	All	All	−0.405	<.001	8	view →
LUSC	Male	All	+0.499	<.001	4	view →
KICH	All	All	−0.580	.003	3	view →
CHOL	All	II,III,IV	+0.815	.004	2	view →
COAD	Male	All	+0.358	.021	2	view →
BRCA	All	II,III,IV	+0.162	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ITCH–BLCA

Open the BLCA breakdown →