ITCH

Across TCGA patient cohorts, ITCH RNA expression is significantly associated with the protein abundance of many other proteins, with 10,576 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ITCH-associated proteins across cancer lineages are RPRD1B, AHCY, and RBM12. Each is linked with ITCH in more than 6 cancer types. Because this analysis shows association rather than direction, both ITCH-to-partner and partner-to-ITCH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITCH versus RPRD1B in LUAD, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ITCH→partner) and Y-score (partner→ITCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPRD1B →	+0.343	+0.363	<.001	<.001	3	7
COAD	AHCY →	+0.405	+0.355	.001	<.001	3	7
PDAC	RBM12 →	+0.248	+0.299	.001	.001	3	5
COAD	CHMP4B →	+0.265	+0.378	<.001	<.001	3	5
PDAC	EIF6 →	+0.363	+0.255	<.001	.001	3	5
COAD	YWHAB →	+0.322	+0.349	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,576 associations by consensus.

ITCH vs RPRD1B — LUAD

Explore this scatter interactively →