ITCH

Across TCGA patient cohorts, ITCH protein abundance is significantly associated with the RNA expression of many other genes, with 10,879 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ITCH-associated genes across cancer lineages are PIGU, TTPAL, and DYNLRB1. Each is linked with ITCH in more than 5 cancer types. Because this analysis shows association rather than direction, both ITCH-to-partner and partner-to-ITCH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ITCH versus PIGU in LSCC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITCH→partner) and Y-score (partner→ITCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIGU →	+0.627	+0.293	<.001	<.001	3	6
COAD	TTPAL →	+0.567	+0.232	<.001	<.001	3	6
COAD	DYNLRB1 →	+0.694	+0.254	<.001	<.001	3	6
COAD	CHMP4B →	+0.476	+0.205	<.001	<.001	3	5
BRCA	EIF2S2 →	+0.600	+0.234	<.001	<.001	3	5
BRCA	EIF6 →	+0.638	+0.215	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,879 associations by consensus.

ITCH vs PIGU — LSCC

Explore this scatter interactively →