ITCH

Across TCGA patient cohorts, ITCH mutation is significantly associated with the RNA expression of many other genes, with 2,785 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITCH-associated genes across cancer lineages are RN7SKP169, RNU6-129P, and LINC02380. Each is linked with ITCH in more than 2 cancer types. Because this analysis shows association rather than direction, both ITCH-to-partner and partner-to-ITCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP169 grouped by ITCH-low versus ITCH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITCH→partner) and Y-score (partner→ITCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP169 →	+0.115	+4.070	.009	.009	3	3
LUSC	RNU6-129P →	+0.210	+3.151	.003	.009	3	2
LUSC	LINC02380 →	+0.209	+3.706	<.001	.003	3	2
BRCA	SOX14 →	+0.438	+4.301	<.001	.008	3	2
UCEC	SRP54 →	+0.357	+1.283	.006	.009	3	2
UCEC	SEC23A →	+0.398	+2.008	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,785 associations by consensus.

RN7SKP169 by ITCH expression — COAD

Explore this box plot interactively →