ITCH

Across TCGA patient cohorts, ITCH mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ITCH-associated genes across cancer lineages are eEF2, eIF4E, and GAPDH. Each is linked with ITCH in more than 1 cancer types. Because this analysis shows association rather than direction, both ITCH-to-partner and partner-to-ITCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ITCH-low versus ITCH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ITCH→partner) and Y-score (partner→ITCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.381	+2.700	.002	.006	3	2
UCEC	eIF4E →	+0.177	+2.070	.015	.001	3	2
UCEC	GAPDH →	+0.425	+1.440	.022	.024	3	2
UCEC	p70-S6K_pT389 →	-0.176	-2.459	.007	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.742	+1.926	<.001	.008	3	2
UCEC	14-3-3_beta →	-0.075	-2.295	.031	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eEF2 by ITCH expression — UCEC

Explore this box plot interactively →