ITCH

Across TCGA cell cohorts, ITCH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,648 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ITCH-associated GO terms across cancer lineages are Protein K29-linked ubiquitination, Mitotic centrosome separation, and Endosomal transport. Each is linked with ITCH in more than 16 cancer types. Because this analysis shows association rather than direction, both ITCH-to-partner and partner-to-ITCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein K29-linked ubiquitination grouped by ITCH-low versus ITCH-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ITCH→partner) and Y-score (partner→ITCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein K29-linked ubiquitination →	+0.163	+0.953	.006	.009	3	17
BREAST	Mitotic centrosome separation →	+0.168	+0.989	<.001	<.001	3	15
STOMACH	Endosomal transport →	+0.053	+0.762	<.001	.002	3	14
OVARY	Golgi vesicle transport →	+0.063	+0.837	<.001	<.001	3	13
STOMACH	Regulation of protein deubiquitination →	+0.197	+1.415	<.001	<.001	3	13
BREAST	Regulation of hematopoietic stem cell differentiation →	+0.127	+0.999	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,648 associations by consensus.

Protein K29-linked ubiquitination by ITCH expression — OESOPHAGUS

Explore this box plot interactively →