ISYNA1

Across TCGA patient cohorts, ISYNA1 mutation is significantly associated with the RNA expression of many other genes, with 3,308 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISYNA1-associated genes across cancer lineages are RN7SL248P, CCL4, and UHRF1. Each is linked with ISYNA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISYNA1-to-partner and partner-to-ISYNA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by ISYNA1-low versus ISYNA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISYNA1→partner) and Y-score (partner→ISYNA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.051	+2.915	<.001	.007	3	2
COAD	CCL4 →	+1.347	+3.183	<.001	.009	3	2
UCEC	UHRF1 →	+0.968	+2.818	<.001	<.001	3	2
UCEC	H2AC14 →	+0.604	+3.823	.001	<.001	3	2
COAD	KIR3DX1 →	+0.093	+3.835	.001	.001	3	2
COAD	ZC3HAV1 →	+0.534	+3.252	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,308 associations by consensus.

RN7SL248P by ISYNA1 expression — UCEC

Explore this box plot interactively →