ISY1

Across TCGA patient cohorts, ISY1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISY1-associated genes across cancer lineages are F8A2, MLECP1, and RNU6-1284P. Each is linked with ISY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISY1-to-partner and partner-to-ISY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F8A2 grouped by ISY1-low versus ISY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISY1→partner) and Y-score (partner→ISY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	F8A2 →	+0.098	+5.694	<.001	.003	3	1
UCEC	MLECP1 →	+0.147	+6.226	.001	.001	3	1
UCEC	RNU6-1284P →	+0.706	+5.186	.004	.007	3	1
UCEC	RNU6-366P →	+0.719	+6.226	<.001	.001	3	1
UCEC	RNU6-1228P →	+0.557	+7.049	<.001	<.001	3	1
UCEC	RNU6-739P →	+0.725	+5.852	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

F8A2 by ISY1 expression — UCEC

Explore this box plot interactively →