ISY1

Across TCGA cell cohorts, ISY1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,781 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ISY1-associated genes across cancer lineages are KCNK12, EIF4G2, and BET1L. Each is linked with ISY1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ISY1-to-partner and partner-to-ISY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISY1 versus KCNK12 in LUNG_NSCLC_LUSC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISY1→partner) and Y-score (partner→ISY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KCNK12 →	+0.290	+0.862	.009	.008	3	4
STOMACH	EIF4G2 →	-0.951	-0.956	.007	.006	3	4
LIVER	BET1L →	-0.651	-0.657	.001	<.001	3	4
LUNG_NSCLC_LUSC	EPB41L4A →	-1.341	-1.032	.006	.005	3	4
LUNG_NSCLC_LUSC	TMTC2 →	-1.305	-0.902	.003	.001	3	4
KIDNEY	MMUT →	+0.914	+0.802	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,781 associations by consensus.

ISY1 vs KCNK12 — LUNG_NSCLC_LUSC

Explore this scatter interactively →