ISY1-RAB43

Across TCGA pan-cancer cohorts, ISY1-RAB43 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ISY1-RAB43 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ISY1-RAB43 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ISY1-RAB43 expression acts as an unfavorable survival marker.

KIRC, LUSC, and UCEC are the cancer types where ISY1-RAB43 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.167	0.655	.038	12	view →
LUSC	OS	Median	II,III,IV	0.216	0.742	.013	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ISY1-RAB43–KIRC (OS)

Open the KIRC breakdown →