ISX

Across TCGA patient cohorts, ISX mutation is significantly associated with the RNA expression of many other genes, with 910 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISX-associated genes across cancer lineages are DPPA2, NUDCD2, and SNORD105. Each is linked with ISX in more than 2 cancer types. Because this analysis shows association rather than direction, both ISX-to-partner and partner-to-ISX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPPA2 grouped by ISX-low versus ISX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISX→partner) and Y-score (partner→ISX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPPA2 →	+0.977	+3.595	<.001	.003	3	3
LUSC	NUDCD2 →	+0.331	+2.565	.006	.009	3	3
UCEC	SNORD105 →	+0.744	+1.981	<.001	.009	3	3
SKCM	BTBD6 →	+0.465	+2.836	.001	.001	3	3
UCEC	DPH3 →	+0.500	+3.210	.005	.009	3	2
UCEC	CHAF1A →	+0.835	+2.606	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 910 associations by consensus.

DPPA2 by ISX expression — UCEC

Explore this box plot interactively →