ISX

Across TCGA pan-cancer cohorts, ISX RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ISX data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ISX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ISX expression acts as an unfavorable survival marker, although some lineages such as LUAD and PAAD show a favorable association.

ACC, KIRC, and UVM are the cancer types where ISX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.546	0.898	<.001	102	view →
KIRC	DFS	Tertile	All	0.461	0.686	<.001	100	view →
UVM	OS	Tertile	All	0.275	0.940	<.001	81	view →
LUAD	OS	Median	All	0.866	0.709	<.001	36	view →
PAAD	OS	Tertile	All	0.795	0.531	.013	32	view →
COAD	OS	Median	II,III,IV	0.862	0.687	.008	27	view →
THYM	DFS	Tertile	All	0.969	0.682	.010	25	view →
TGCT	DFS	Tertile	All	0.707	0.898	.013	18	view →
PCPG	DFS	Tertile	All	0.470	0.897	.017	18	view →
UCS	DFS	Tertile	II,III,IV	0.552	0.169	.013	16	view →
CHOL	DFS	Quartile	III,IV	0.031	0.452	.017	15	view →
UCEC	OS	Median	All	0.829	0.893	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ISX–ACC (OS)

Open the ACC breakdown →