ISX

Across TCGA cell cohorts, ISX RNA expression is significantly associated with the go_rna of many other GO terms, with 1,753 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISX-associated GO terms across cancer lineages are Oocyte growth, Negative regulation of DNA-templated transcription initiation, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with ISX in more than 5 cancer types. Because this analysis shows association rather than direction, both ISX-to-partner and partner-to-ISX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Oocyte growth grouped by ISX-low versus ISX-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISX→partner) and Y-score (partner→ISX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Oocyte growth →	+0.156	+1.616	.003	.009	3	6
SKIN	Negative regulation of DNA-templated transcription initiation →	+0.097	+0.029	<.001	.001	3	4
SKIN	Negative regulation of transcription initiation by RNA polymerase II →	+0.097	+0.029	<.001	.001	3	4
CNS	Protein to membrane docking →	+0.047	+0.019	.004	.005	3	4
LIVER	Primary amino compound biosynthetic process →	+1.861	+2.034	<.001	.001	3	4
LIVER	Serotonin biosynthetic process →	+1.913	+1.193	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,753 associations by consensus.

Oocyte growth by ISX expression — LIVER

Explore this box plot interactively →