ISX

Across TCGA cell cohorts, ISX mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISX-associated genes across cancer lineages are INSRR, TAS2R7, and RXFP2. Each is linked with ISX in more than 1 cancer types. Because this analysis shows association rather than direction, both ISX-to-partner and partner-to-ISX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INSRR grouped by ISX-low versus ISX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISX→partner) and Y-score (partner→ISX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	INSRR →	+0.028	+3.584	<.001	.007	3	2
LUNG_NSCLC_LUAD	TAS2R7 →	+0.031	+3.734	<.001	.006	3	1
LUNG_NSCLC_LUAD	RXFP2 →	+0.051	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.292	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	LILRA5 →	+0.030	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	ZCCHC13 →	+0.014	+4.681	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

INSRR by ISX expression — LARGE_INTESTINE

Explore this box plot interactively →