ISX

Across TCGA cell cohorts, ISX mutation is significantly associated with the mutation status of many other genes, with 3,685 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISX-associated genes across cancer lineages are SPHKAP, OCA2, and GAS2L2. Each is linked with ISX in more than 3 cancer types. Because this analysis shows association rather than direction, both ISX-to-partner and partner-to-ISX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPHKAP grouped by ISX-low versus ISX-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISX→partner) and Y-score (partner→ISX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPHKAP →	+2.415	+4.108	.003	.003	1	4
CNS	OCA2 →	+4.614	+4.614	.006	.006	1	3
LARGE_INTESTINE	GAS2L2 →	+2.152	+2.787	.005	.005	1	3
SKIN	ANKRD30A →	+1.924	+3.820	.004	.004	1	3
SKIN	PCDH11X →	+3.187	+3.963	.001	.001	1	3
SKIN	ACAD10 →	+3.187	+3.963	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,685 associations by consensus.

SPHKAP by ISX expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →