ISOC2

Across TCGA patient cohorts, ISOC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,627 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ISOC2-associated proteins across cancer lineages are HSPBP1, KIF1C_S1092, and RRM2. Each is linked with ISOC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ISOC2-to-partner and partner-to-ISOC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISOC2 versus HSPBP1 in OV, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISOC2→partner) and Y-score (partner→ISOC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HSPBP1 →	+0.343	+0.633	<.001	<.001	3	6
OV	KIF1C_S1092 →	-1.083	-0.738	.001	.002	3	3
COAD	RRM2 →	+0.491	+0.376	<.001	.008	3	3
GBM	ATG16L1 →	-0.196	-0.295	.001	.009	3	3
LSCC	SLC1A5 →	+0.576	+0.485	<.001	<.001	3	3
COAD	SMC4 →	+0.478	+0.455	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,627 associations by consensus.

ISOC2 vs HSPBP1 — OV

Explore this scatter interactively →