ISM1

Across TCGA pan-cancer cohorts, ISM1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ISM1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ISM1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ISM1 expression acts as an unfavorable survival marker.

KIRP, LUSC, and STAD are the cancer types where ISM1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.037	0.920	<.001	24	view →
LUSC	OS	Median	All	0.391	0.777	.004	24	view →
STAD	OS	Median	All	0.199	0.730	.004	12	view →
READ	OS	Median	All	0.166	0.830	<.001	12	view →
SARC	DFS	Median	All	0.158	0.614	.002	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	All	0.424	0.736	.004	5	view →
LGG	OS	Median	All	0.306	0.799	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ISM1–KIRP (DFS)

Open the KIRP breakdown →