ISM1

Across TCGA pan-cancer cohorts, ISM1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ISM1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ISM1 RNA is repressed in tumor relative to normal tissue. In most cancer types ISM1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where ISM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ISM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−3.235	<.001	10	view →
KICH	Female	All	−1.916	<.001	10	view →
BRCA	Female	II,III,IV	−2.129	<.001	6	view →
COAD	All	All	+0.629	.002	6	view →
READ	Male	All	+1.700	.014	5	view →
LUAD	All	All	+0.836	<.001	5	view →
BLCA	Female	III,IV	+1.321	.013	3	view →
UCEC	All	All	+0.826	.036	2	view →
PRAD	All	All	−0.364	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ISM1–THCA

Open the THCA breakdown →