ISM1

Across TCGA patient cohorts, ISM1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,212 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ISM1-associated proteins across cancer lineages are SERBP1, SGCD, and SORBS1. Each is linked with ISM1 in more than 6 cancer types. Because this analysis shows association rather than direction, both ISM1-to-partner and partner-to-ISM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISM1 versus SERBP1 in OV, with a Pearson correlation of -0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM1→partner) and Y-score (partner→ISM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERBP1 →	-0.355	-1.492	<.001	<.001	3	7
BRCA	SGCD →	+0.724	+1.359	<.001	<.001	3	7
BRCA	SORBS1 →	+0.728	+1.147	<.001	<.001	3	7
BRCA	YME1L1 →	-0.306	-1.069	<.001	<.001	3	7
OV	CDH13 →	+0.742	+1.844	<.001	<.001	3	7
BRCA	CNN1 →	+0.966	+1.391	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,212 associations by consensus.

ISM1 vs SERBP1 — OV

Explore this scatter interactively →