ISM1

Across TCGA patient cohorts, ISM1 mutation is significantly associated with the RNA expression of many other genes, with 1,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISM1-associated genes across cancer lineages are SPATA31D5P, RN7SL861P, and ACTBP7. Each is linked with ISM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISM1-to-partner and partner-to-ISM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D5P grouped by ISM1-low versus ISM1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM1→partner) and Y-score (partner→ISM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SPATA31D5P →	+0.007	+4.653	<.001	.007	3	2
READ	RN7SL861P →	+0.373	+4.724	<.001	.003	3	2
SKCM	ACTBP7 →	+0.520	+3.341	<.001	.005	3	2
SKCM	RNA5SP502 →	+0.223	+3.179	<.001	.007	3	2
SKCM	TXN2P1 →	+0.192	+3.732	.002	.002	3	2
HNSC	IGHVII-46-1 →	+1.490	+5.578	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,586 associations by consensus.

SPATA31D5P by ISM1 expression — READ

Explore this box plot interactively →