ISM1

Across TCGA cell cohorts, ISM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,928 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ISM1-associated GO terms across cancer lineages are Trunk segmentation, Trunk neural crest cell migration, and Ventral trunk neural crest cell migration. Each is linked with ISM1 in more than 8 cancer types. Because this analysis shows association rather than direction, both ISM1-to-partner and partner-to-ISM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trunk segmentation grouped by ISM1-low versus ISM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM1→partner) and Y-score (partner→ISM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Trunk segmentation →	+0.865	+1.134	<.001	.004	3	9
BONE	Trunk neural crest cell migration →	+0.865	+1.134	<.001	.004	3	9
BONE	Ventral trunk neural crest cell migration →	+0.865	+1.134	<.001	.004	3	9
BLOOD_Lymphoma	Spermatid differentiation →	-0.026	-0.485	<.001	.003	3	7
BONE	Positive regulation of focal adhesion assembly →	+0.224	+0.971	<.001	.009	2	7
BONE	Regulation of epithelial to mesenchymal transition →	+0.094	+1.091	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,928 associations by consensus.

Trunk segmentation by ISM1 expression — BONE

Explore this box plot interactively →