ISM1

Across TCGA cell cohorts, ISM1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISM1-associated genes across cancer lineages are FIGLA, ZSCAN1, and TBL1Y. Each is linked with ISM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISM1-to-partner and partner-to-ISM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FIGLA grouped by ISM1-low versus ISM1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM1→partner) and Y-score (partner→ISM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FIGLA →	+0.253	+5.285	<.001	.003	3	2
PANCREAS	ZSCAN1 →	+0.039	+5.000	<.001	.006	3	1
PANCREAS	TBL1Y →	+0.006	+5.614	<.001	.002	3	1
CNS	OR2F2 →	+0.030	+6.357	<.001	<.001	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
SKIN	BTN1A1 →	+0.216	+4.095	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FIGLA by ISM1 expression — STOMACH

Explore this box plot interactively →