ISM1

Across TCGA cell cohorts, ISM1 mutation is significantly associated with the mutation status of many other genes, with 4,224 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISM1-associated genes across cancer lineages are ROBO2, NOD2, and ACAP1. Each is linked with ISM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ISM1-to-partner and partner-to-ISM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ROBO2 grouped by ISM1-low versus ISM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISM1→partner) and Y-score (partner→ISM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ROBO2 →	+1.992	+3.963	.001	.001	1	5
PANCREAS	NOD2 →	+5.115	+5.115	.005	.005	1	4
OVARY	ACAP1 →	+4.415	+4.977	.007	.007	1	4
SKIN	MSH3 →	+5.053	+4.239	.007	.007	1	4
BLOOD_Leukemia	ZNF835 →	+2.894	+4.432	.005	.005	1	4
BLOOD_Leukemia	TICRR →	+3.672	+5.083	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,224 associations by consensus.

ROBO2 by ISM1 expression — LARGE_INTESTINE

Explore this box plot interactively →