ISLR

Across TCGA pan-cancer cohorts, ISLR mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ISLR’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ISLR mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ISLR is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LUAD, PDAC, and CCRCC are the cancer types where ISLR tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ISLR mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.238	<.001	7	view →
PDAC	Male	II,III,IV	+1.047	<.001	6	view →
CCRCC	Male	III,IV	−0.615	<.001	6	view →
LSCC	All	All	+0.143	.028	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ISLR–LUAD

Open the LUAD breakdown →