ISLR

Across TCGA pan-cancer cohorts, ISLR RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ISLR data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ISLR RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ISLR expression acts as an unfavorable survival marker, although some lineages such as UCS and UCEC show a favorable association.

KIRP, ACC, and UCS are the cancer types where ISLR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.513	0.960	<.001	94	view →
ACC	DFS	Quartile	All	0.156	0.807	<.001	41	view →
UCS	DFS	Quartile	II,III,IV	0.632	0.117	.003	36	view →
UCEC	DFS	Median	II,III,IV	0.872	0.771	.003	34	view →
BLCA	OS	Tertile	All	0.347	0.614	.004	27	view →
HNSC	DFS	Median	IV	0.603	0.481	.006	18	view →
LUAD	OS	Quartile	II,III,IV	0.560	0.305	.007	18	view →
LGG	OS	Median	All	0.860	0.929	.003	12	view →
SKCM	DFS	Median	IV	0.602	0.273	.027	9	view →
MESO	DFS	Median	IV	0.449	0.178	.008	9	view →
CHOL	DFS	Tertile	All	0.787	0.123	.028	9	view →
THCA	DFS	Median	All	0.889	0.766	.007	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ISLR–KIRP (OS)

Open the KIRP breakdown →