ISLR

Across TCGA patient cohorts, ISLR RNA expression is significantly associated with the protein abundance of many other proteins, with 20,823 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ISLR-associated proteins across cancer lineages are RCN3, RSU1, and ASPN. Each is linked with ISLR in more than 9 cancer types. Because this analysis shows association rather than direction, both ISLR-to-partner and partner-to-ISLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISLR versus RCN3 in GBM, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR→partner) and Y-score (partner→ISLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCN3 →	+0.851	+1.471	<.001	<.001	3	10
UCEC	RSU1 →	+0.682	+1.179	<.001	<.001	3	10
OV	ASPN →	+1.568	+1.576	<.001	<.001	3	10
OV	SERPINF1 →	+0.998	+1.843	<.001	<.001	3	10
BRCA	SERPINH1 →	+0.857	+1.546	<.001	<.001	3	10
CCRCC	SFRP4 →	+1.631	+2.317	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,823 associations by consensus.

ISLR vs RCN3 — GBM

Explore this scatter interactively →