ISLR

Across TCGA patient cohorts, ISLR protein abundance is significantly associated with the RNA expression of many other genes, with 13,607 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible ISLR-associated genes across cancer lineages are MYL9, PCOLCE, and SFRP4. Each is linked with ISLR in more than 9 cancer types. Because this analysis shows association rather than direction, both ISLR-to-partner and partner-to-ISLR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISLR versus MYL9 in COAD, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR→partner) and Y-score (partner→ISLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYL9 →	+1.283	+0.519	<.001	<.001	3	10
OV	PCOLCE →	+1.146	+0.612	<.001	<.001	3	10
OV	SFRP4 →	+2.413	+0.866	<.001	<.001	3	10
BRCA	ASPN →	+2.126	+0.759	<.001	<.001	3	10
OV	ACTA2 →	+1.702	+0.722	<.001	<.001	3	10
BRCA	SPARC →	+1.560	+0.904	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,607 associations by consensus.

ISLR vs MYL9 — COAD

Explore this scatter interactively →