ISLR

Across TCGA patient cohorts, ISLR mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ISLR-associated genes across cancer lineages are FASN, Acetyl-a-Tubulin-Lys40, and Shc_pY317. Each is linked with ISLR in more than 1 cancer types. Because this analysis shows association rather than direction, both ISLR-to-partner and partner-to-ISLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ISLR-low versus ISLR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR→partner) and Y-score (partner→ISLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.525	+2.321	.001	.006	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.518	+3.179	.013	.010	3	2
UCEC	Shc_pY317 →	-0.198	-2.321	.001	.006	3	2
UCEC	c-Met_pY1235 →	+0.082	+2.321	.007	.006	3	2
UCEC	C-Raf →	+0.326	+2.906	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.877	+3.000	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

FASN by ISLR expression — UCEC

Explore this box plot interactively →