ISLR

Across TCGA cell cohorts, ISLR RNA expression is significantly associated with the go_rna of many other GO terms, with 2,311 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ISLR-associated GO terms across cancer lineages are Retinol transport, Isoprenoid transport, and Terpenoid transport. Each is linked with ISLR in more than 12 cancer types. Because this analysis shows association rather than direction, both ISLR-to-partner and partner-to-ISLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Retinol transport grouped by ISLR-low versus ISLR-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR→partner) and Y-score (partner→ISLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Retinol transport →	+1.451	+0.761	<.001	<.001	2	13
SOFT_TISSUE	Isoprenoid transport →	+1.428	+2.308	<.001	<.001	3	11
SOFT_TISSUE	Terpenoid transport →	+1.428	+2.308	<.001	<.001	3	11
SKIN	Paramesonephric duct development →	+1.258	+1.421	<.001	<.001	3	10
BREAST	Positive regulation of cytoplasmic translation →	+0.118	+0.896	<.001	.005	1	9
UPPER_AERODIGESTIVE_TRACT	Regulation of cellular response to heat →	+0.101	+0.625	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,311 associations by consensus.

Retinol transport by ISLR expression — LUNG_SCLC

Explore this box plot interactively →