ISLR

Across TCGA cell cohorts, ISLR mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISLR-associated genes across cancer lineages are MAGEB4, CAMP, and LRRC3C. Each is linked with ISLR in more than 1 cancer types. Because this analysis shows association rather than direction, both ISLR-to-partner and partner-to-ISLR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by ISLR-low versus ISLR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISLR→partner) and Y-score (partner→ISLR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	CAMP →	+0.341	+3.643	<.001	.005	3	1
LARGE_INTESTINE	LRRC3C →	+0.289	+3.658	<.001	.005	3	1
LARGE_INTESTINE	GPX5 →	+0.271	+3.688	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
CNS	PNMA6F →	+0.006	+4.981	.007	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

MAGEB4 by ISLR expression — LARGE_INTESTINE

Explore this box plot interactively →