ISL2

Across TCGA pan-cancer cohorts, ISL2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ISL2 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ISL2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ISL2 expression acts as an unfavorable survival marker.

SKCM, ESCA, and UCEC are the cancer types where ISL2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.029	0.691	<.001	30	view →
ESCA	DFS	Median	II,III,IV	0.159	0.525	.009	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	OS	Median	All	0.188	0.669	.041	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ISL2–SKCM (DFS)

Open the SKCM breakdown →