ISL2

Across TCGA patient cohorts, ISL2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,819 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ISL2-associated proteins across cancer lineages are SPAST, VAV1, and CAD. Each is linked with ISL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ISL2-to-partner and partner-to-ISL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISL2 versus SPAST in LSCC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL2→partner) and Y-score (partner→ISL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPAST →	+0.372	+0.409	<.001	<.001	3	5
BRCA	VAV1 →	+0.474	+0.354	<.001	<.001	3	4
BRCA	CAD →	+0.281	+0.368	<.001	<.001	3	4
OV	DOCK11 →	+0.521	+0.237	<.001	<.001	3	4
BRCA	MUC1 →	-0.744	-0.300	<.001	.005	3	4
BRCA	ACAP1 →	+0.448	+0.288	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,819 associations by consensus.

ISL2 vs SPAST — LSCC

Explore this scatter interactively →