ISL2

Across TCGA cell cohorts, ISL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,819 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ISL2-associated GO terms across cancer lineages are Nucleic acid catabolic process, Negative regulation of gene expression, epigenetic, and Heterochromatin organization. Each is linked with ISL2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ISL2-to-partner and partner-to-ISL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid catabolic process grouped by ISL2-low versus ISL2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL2→partner) and Y-score (partner→ISL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Nucleic acid catabolic process →	+0.044	+0.834	<.001	<.001	3	8
LARGE_INTESTINE	Negative regulation of gene expression, epigenetic →	+0.050	+0.991	.001	.002	3	8
BLOOD_Lymphoma	Heterochromatin organization →	+0.040	+0.781	<.001	<.001	3	8
SOFT_TISSUE	Leukocyte mediated immunity →	-0.077	-1.078	<.001	<.001	3	7
BONE	Negative regulation of transcription elongation by RNA polymerase II →	+0.104	+0.890	.003	.006	3	7
BONE	Nucleic acid transport →	+0.091	+1.213	.004	<.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,819 associations by consensus.

Nucleic acid catabolic process by ISL2 expression — BLOOD_Lymphoma

Explore this box plot interactively →