ISL2

Across TCGA cell cohorts, ISL2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ISL2-associated genes across cancer lineages are CLUAP1, PRPSAP2, and PTH2R. Each is linked with ISL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ISL2-to-partner and partner-to-ISL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLUAP1 grouped by ISL2-low versus ISL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISL2→partner) and Y-score (partner→ISL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CLUAP1 →	+0.616	+3.215	.009	.009	3	1
LARGE_INTESTINE	PRPSAP2 →	+0.765	+3.064	<.001	.009	3	1
LARGE_INTESTINE	PTH2R →	+0.604	+2.938	.003	.003	3	1
LARGE_INTESTINE	PNLDC1 →	+0.074	+3.302	.001	.008	3	1
LARGE_INTESTINE	CERS3 →	+0.408	+2.900	.003	.002	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.060	+2.938	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

CLUAP1 by ISL2 expression — LARGE_INTESTINE

Explore this box plot interactively →