ISCU

Across TCGA patient cohorts, ISCU protein abundance is significantly associated with the RNA expression of many other genes, with 14,958 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ISCU-associated genes across cancer lineages are NFS1, RLF, and ADM. Each is linked with ISCU in more than 5 cancer types. Because this analysis shows association rather than direction, both ISCU-to-partner and partner-to-ISCU results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ISCU versus NFS1 in COAD, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ISCU→partner) and Y-score (partner→ISCU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NFS1 →	+0.609	+0.270	<.001	<.001	3	6
BRCA	RLF →	-0.507	-0.410	.001	<.001	3	6
PDAC	ADM →	-1.181	-0.185	.002	.008	3	5
CCRCC	SRSF3 →	-0.326	-0.265	<.001	<.001	3	5
GBM	CENPI →	-0.756	-0.226	<.001	.002	3	5
BRCA	ENO1 →	-0.864	-0.406	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,958 associations by consensus.

ISCU vs NFS1 — COAD

Explore this scatter interactively →