ISCU

Across TCGA pan-cancer cohorts, ISCU RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ISCU data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher ISCU RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ISCU expression acts as an unfavorable survival marker, although some lineages such as UCS and CESC show a favorable association.

UCS, CESC, and UVM are the cancer types where ISCU RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	III,IV	0.594	0.230	.001	78	view →
CESC	OS	Median	All	0.870	0.720	<.001	56	view →
UVM	DFS	Quartile	II,III,IV	0.296	0.685	.006	56	view →
KIRP	DFS	Median	All	0.976	0.792	.006	49	view →
ACC	OS	Median	II,III,IV	0.874	0.647	.002	40	view →
PAAD	DFS	Tertile	All	0.409	0.189	.001	36	view →
SARC	DFS	Median	All	0.701	0.521	<.001	35	view →
BRCA	OS	Quartile	III,IV	0.983	0.816	.001	25	view →
BLCA	DFS	Median	All	0.561	0.452	.006	24	view →
UCEC	DFS	Quartile	III,IV	0.913	0.708	.002	20	view →
LGG	OS	Quartile	All	0.702	0.847	.001	18	view →
DLBC	DFS	Median	II,III,IV	0.427	0.932	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ISCU–UCS (DFS)

Open the UCS breakdown →